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Alzheimer's: Genetic Dementia - Term Papers

Alzheimer's: Genetic Dementia

Alzheimer's, the disease of the degeneration of the brain, was
identified in 1907 by German physician Alois Alzheimer. Four million
Americans suffer from the disease which deprives the victim of the ability
to remember, think, reason, and eventually coordinate movement. This most
common form of dementia is caused physically by the gradual change in nerve
cells, which leads to the destruction of brain cells. Studies find that
this fourth leading cause of death affects more women than men, and more
Hispanics and African-Americans than Caucasians. The disease can be
present in two forms; early onset Alzheimer's affects those younger than
age 65, whereas late onset Alzheimer's affects ...

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APOE-e4 are not guaranteed
to develop the disease. APOE-e4 may simply be unable to efficiently repair
nerve cells. The presence of e4 does not signify if person will develop
Alzheimer's; instead, it signifies when he or she will get it. Recent
studies suggest that Alzheimer's may be affected by an interaction between
APOE and the newly discovered risk factor alpha-2-macrogobulin, A2M, a gene
mutation on chromosome 12. A2M is a protein that deactivates proteases,
enzymes that carve up other proteins. Alpha-2-macrogobulin's involvement
in Alzheimer's development is especially likely because it attaches to the
same cell surface protein as APOE and amyloid precursor-protein (APP). The
unmutated form of A2M helps to get rid of the APP fragment beta-amyloid,
which is present in excess amounts in the brains of Alzheimer's patients.
The mutant A2M, which does not properly remove protein, but only makes the
aging brain vulnerable; it does not guarantee affliction.
Another ...

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Alzheimer's: Genetic Dementia. (2006, July 24). Retrieved June 1, 2026, from http://www.essayworld.com/essays/Alzheimers-Genetic-Dementia/49641

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PAPER DETAILS

Added: 7/24/2006 03:22:13 PM
Category: Health & Medicine
Type: Premium Paper
Words: 899
Pages: 4

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