PP2A inhibitors induce apoptosis in pancreatic cancer cell line PANC-1 through persistent phosporylation of IKK and sustained activation of the NF-kB

The collective 1-year survival from the time of diagnosis at any stage is only 26%, while 5-yuear survival falls down to <5%. The main reason for such poor outcomes is mostly due to the fact that the first diagnosis is made at late stages and its overall resistance to available therapies. Even patients undergoing surgical therapy at early stages often suffer from disease recurrence or metastatic disease.

PP2A is a multimetric serine/threonine phosphatase which can dephosphorylate several kinases. Cantharidin is a potent and selective inhibitor of PP2A, suggesting its anti-cancer effect might involve the inhibition of this phosphatase. NF-kB pathway plays a pivotal role in the expression ...

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and OA is considered to be carcinogenic.

PP2A inhibitors, cantharidin and OA, had strong anti-tumor activities against pancreatic cancer cell line PANC-1 through persistent activation of the NF-kB pathway. Treatment with PP2A inhibitors induced phosphorylation of IKKa, phosphorylation and degration of IkBa, and nuclear translocation of p65. Activated NF-kB triggered apoptosis through extrinsic pathway and inhibited cellular viability. Cytotoxicity effect was probably due to the elevated expression of downstream pro-apoptotic genes.

In the present study, PP2A inihibitors induce extrinsic apoptosis and inhibit cell viability in pancreatic cancer cell line PANC-1 through persistent activation of the NF-kBpathway. The cytotoxity effect is probably due to the selective elevation of downstream pro-apoptotic genes. Our findings provide convincing evidence for how PP2A inihibitors carry out anti-tumor effects and reveal the possibility of using PP2A as a therapeutic target for ...

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PP2A inhibitors induce apoptosis in pancreatic cancer cell line PANC-1 through persistent phosporylation of IKK and sustained activation of the NF-kB. (2011, April 6). Retrieved January 22, 2018, from http://www.essayworld.com/essays/PP2A-inhibitors-induce-apoptosis-pancreatic-cancer/97767
"PP2A inhibitors induce apoptosis in pancreatic cancer cell line PANC-1 through persistent phosporylation of IKK and sustained activation of the NF-kB." Essayworld.com. Essayworld.com, 6 Apr. 2011. Web. 22 Jan. 2018. <http://www.essayworld.com/essays/PP2A-inhibitors-induce-apoptosis-pancreatic-cancer/97767>
"PP2A inhibitors induce apoptosis in pancreatic cancer cell line PANC-1 through persistent phosporylation of IKK and sustained activation of the NF-kB." Essayworld.com. April 6, 2011. Accessed January 22, 2018. http://www.essayworld.com/essays/PP2A-inhibitors-induce-apoptosis-pancreatic-cancer/97767.
"PP2A inhibitors induce apoptosis in pancreatic cancer cell line PANC-1 through persistent phosporylation of IKK and sustained activation of the NF-kB." Essayworld.com. April 6, 2011. Accessed January 22, 2018. http://www.essayworld.com/essays/PP2A-inhibitors-induce-apoptosis-pancreatic-cancer/97767.
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PAPER DETAILS
Added: 4/6/2011 09:51:03 PM
Submitted By: doyouaiya
Category: Biology
Type: Free Paper
Words: 324
Pages: 2

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